METEOROLOGY OF 1854

Meteorology and Agroforestry Meteorology and Agroforestry

The physical environment affects and interacts with agroforestry systems through tree and crop growth, animal performance, management operations and interactions between the tree/shrub and non-tree components (abbreviated to tree/crop interactions). Interactions take place mainly through the media of microclimate, soil moisture and soil. They may have beneficial or adverse effects, for tree and...

Physical Meteorology

Dmd065748 1847..1854

The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined. OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (PAH) and 6-carboxyfluorescein were the substrates. Most compounds (10 of 14) inhibited competitively, increasing the Michaelis constant (Km) without affecting the maximal transport rate (Jmax). Others were mixed-type (lowe...

Ddf189 1845..1854

Autosomal dominant polycystic kidney disease (ADPKD) occurs by germline mutation in PKD1 or PKD2. Evidence of homozygous inactivation of either gene in human cyst lining cells as well as in mouse knockout models strongly supports a two-hit mechanism for cyst formation. Discovery of trans-heterozygous mutations in PKD1 and PKD2 in a minority of human renal cysts has led to the proposal that such...

Op-cbio150070 1854..1856

Motivation: Adoptive T cell therapies based on introduction of new T cell receptors (TCRs) into patient recipient T cells is a promising new treatment for various kinds of cancers. A major challenge, however, is the choice of target antigens. If an engineered TCR can cross-react with self-antigens in healthy tissue, the side-effects can be devastating. We present the first web server for assess...